Spotnose Wobble?

[t_h_wyman]

@necromorphs

If you have any questions, need clarification, or would like me to discuss any of these topics in more detail please let me know.

As Ashley notes, I do indeed have a very clear understanding of how genetics works
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@necromorphs

I know tone of voice can be hard to portray over text post so I hope I didn’t come off as trying to correct you!

Eh, maybe a little bit. But I mostly have a pretty thick skin and it is generally hard to ruffle my feathers. So we are all good
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@necromorphs

If you have additional information or resources I would love to check them out!

Nothing I can point to specifically, just a few decades immersed in the hobby and waaaaaaaaaaaaaaaaaaaaaaaaaaaaaaay too many hours in school and the lab LOL
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@necromorphs

Without genetic sequencing of both morphs and identification of the genomic sequence causing the wobble we can’t say for certain it is the same mutation

You very certainly do not need genetic sequencing. Spotnose and Spider are not the same mutation because if they were the same then the phenotype would be the same. However, it is possible, some might even say probable, that they are different mutation to the same gene. We would not need sequencing to know that. Given that it has been shown that Spider and Blackhead are allelic, if you were to breed a Blackhead to a Spotnose and get the combo and then breed the combo out and get only BH and Spotnose animals with no BH/Spot combo and no WT then you will have shown that these two mutations are also allelic and, therefore, mutations to the same gene. Much easier and cheaper than sequencing

I have seen a very large trend in the hobby of late to jump to “linkage” as being the cause for things these days. While linkage phenomena are certainly known in balls (looking at you Banana/CG… ) it is more parsimonious explanation for “wobble” is that the gene in question that is shared between all the known allelic morphs, and suspected for the others, is one that has an essential function and disruption of that function results in the secondary extended phenotype.

If you have not already seen this preprint (and also, please take not of my caveat in the post), you might find it interesting. And also better understand my argument for parsimony:

Ethics of Spiders and Spider Breeding

VERY IMPORTANT TO NOTE BEFORE CLICKING AND READING THE BELOW: THIS IS A PRE-PRINT! IT HAS NOT BEEN PEER REVIEWED! THE CONCLUSIONS HAVE NOT BEEN SUBJECT TO EVALUATION BY OUTSIDE SCIENTIST! THERE IS NO GUARANTEE THE INFORMATION HEREIN WILL STAND UP TO SCRUTINY (Also, I have not had a chance to read it yet myself so I am neither endorsing nor condemning it at this time)