Besides the 48 hours they require to digest after I feed, I handle mine every day.
I usually do 20 minutes in the early mornings around 2am, then before I head to work I get another quick handle in for about 5 mins.
When I get home from work I try and have each one out for a hour.
But I keep reticulated pythons and they need to be trained more than the average snake. They don’t stress like some species( most commonly balls) when handled every day. And when you can have a snake that can reach long lengths, they need to be tame and confident when out.
Also I find the best way to give your snakes enrichment is to offer them time outside their enclosure.
When I used to breed, I would handle daily too, just not as long of a time frame. When you have a lot of hatchlings and or snakes, you can only handle so much.