When are you noticing this spillage of water/drool? When you’re handling it? If a snake regurges water when handled, you might just be stressing it after a long drink. Stuck shed helps confirm this snake may have simply been thirsty. You may as well pick up a snake that just finished downing a meal, you’ll get a regurge.
If it’s straight liquid, let your animal relax and replenish fluids for a few days without handling. Regurgitation is a flight tactic that occurs easily with poorly timed handling.
A thicker, more viscous discharge is more reason for concern, especially if bit isn’t clear. Again, if you’re handling it and noticing it, it may still be a regurge out of stress/flight syndrome.
Stress works wonders on snakes, ball pythons are no exception. A new arrival should be given time to acclimate. Constant handling will extend the acclimation period long enough for other health issues to develop.
Constant regurgitation, be it water or food, will irritate the snake’s throat/digestive tract as much as a person suffering chronic heartburn. You can wind up with an animal incapable of ingesting anything, which will undoubtedly lead to even more severe issues.
I understand that some snakes acclimate easily with frequent handling. We are not all Dr. Doolittle when it comes to acclimating a new pet snake. Allow a few days at minimum in an adequate enclosure to adjust, without handling. A week is more ideal. A successful feeding is good indication that a new addition is relaxing in it’s new environment.