Reticulated python breathing

I’ve had my female retic for quite sometime and when I handling I can hear her breathing when she’s by my face. That’s normal because of their size right? She’s in a 6x4x2 ap cage.

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“Normal” depends on what the breathing sounds like. A very faint hissing/whistling is not uncommon. A gargling/crackling/burbling is not


As said above if it sounds like breathing, or a light whistle it’s fine. If it’s a bubbling sound or a gargle it’s not. If it’s a bubbling/gargle then it could be an RI which requires a culture from a herp specialized vet.