José complex chronic respiratory illness

José Jalapenio is experiencing another major respiratory episode. This episode reminds me of the first one he initially had when i bought him 6 years ago. He has been taken to the vet twice since it started and has been on a rigorous treatment plan for a month and a half with no results.

I’d like to take this time to discuss chronic respiratory illness and what it looks like with my José as the example.

I have on multiple accounts explained José and his history on MMRC, but for anyone in the future who believes they may be battling something like this with one of their snakes, I will touch on it again here.

José was bought at 2.5 years. He was kept in a 20 gallon fish tank with sodden cocoa fiber, a flukers water bowl, and a grapewood jungle gym-like decoration on a heat mat without a thermostat. It is my understanding that he had lived in that setup for all of his life up to that point. He had one home before me that I know nothing about except that he wasn’t doing well with them. We later discovered that his grape vine jungle gym and water bowl were infected with black mold. These two items being in his enclosure for all of his life up age 3.5. His substrate was constantly molding despite f10 cleanings, bleach soakings, frequent spot cleans, etc.
My vet strongly suspects this long term exposure to be the cause of his chronic respiratory distress. As i have been all but certain of myself for a number of years.

The symptoms of his condition are:
Long term reoccurring respiratory infections without husbandry or stress based cause. Treatment resistant. Chronic and intense sensitivity to temp/humidity fluctuations, sanitation, and stress.
Constant pacing in enclosure, obvious distress, refusing food, and visible red nose in early stages.
Wheezing, mucus build up in the throat, gaping, facial sensitivity, flinching to touch, and lethargy in later stages.

He was given ceftazidime injections every three days initially with f10 Nebulization twice daily.
The meds did not work. His condition continued to worsen. So we are testing for the presence of fungus living in the airways, what to treat with, and for Josés medical resistances. We placed him on Azithromyacin Nebulization and continued the ceftazidime while awaiting results which should come in two weeks.

The difficulty of this illness that José has is how much more difficult he is to care for than a ball python should be. It seems sometimes like trying to prevent him from getting sick is impossible. Like all ot takes is holding him 5 minutes too long one time on a Tuesday. Like, if you can’t catch the most subtle warning signs and jump on it right away, he will decline FAST. It’s like I am caring for something between a Panther Chameleon and a dragon snake. Not a ball python. And with the resistances, if an episode progresses too far like this most recent one he is experiencing, thanks to the situation my animals and I are in, it feels like getting him back to health is next to impossible.

The vet he is seeing now thinks that this is all happening because while the infection flare ups may have been treated in previous mini-episodes, the actual fungus that started it is still living, IN his lungs. And the episodes will not stop until that is removed. Except that with the number of infections he has had over the years, there may be so much scar tissue in there even after the fact that he very well could continue to have respiratory issues and return infections for the rest of his life. Had this been caught sooner, maybe he could have been cured.

At this point, the plan is to wait for the results and go from there. If i can find a med/antifungal that will remove the mold from his lungs, i will try that. If i can get him to health again i will be thankful. But if he does not respond to the final treatment, or if he has one more of these major episodes after the fact, then I am going to look into my options for euthanasia.

In any case, he is not going to live to be 35 like he should. He will be very lucky to live to be 15. I am at least hoping to see him live to be 10. But there is no way to tell until we see the results of this last test and treatment.

If he does pass, I would think that his body could be used to contribute to medical research. I cannot afford an autopsy in the event of it happening, but I would be open to letting someone take him to dissect if they would be interested in using him to learn more about chronic respiratory illnesses in snakes. I think it would almost be worth it to have his condition put to use to help save the lives of future exotics.
I would like his remains back at some point to be cremated, that would be my only catch.

Let this be a reminder of the dangers of mold. Cleanliness is next to godliness.

If you have an animal that struggles with frequent respiratory infections, frequent health problems of any kind, don’t stop at initial treatment. Keep going until you can get answers. The biggest barrier to getting my animal care was the veterinarians telling me that it’s got to be SOME kind of husbandry issue. I wasted so much time trying so many different things with his setups. He’s been to almost everye exotics vet in 50 miles of me. If you honestly don’t think it’s a husbandry problem, or that it’s a quick fix, and you have double triple checked every parameter, listen to your gut. Don’t let inexperienced vets talk you into mistrusting yourself. Try a different vet as many times as it takes and insist to get the care that your animal needs

I love José. I’m going to miss him when he’s gone. Let’s hope his new vet and i can get this under control and give him a couple more good years before it’s time.


You can see the red nose he gets earlier on here.

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I’m very sorry you’ve had so much trouble, I know what it’s like to experience chronic health issues both as a human and on behalf of my pets.

Forgive me, I am new to Jose’s story so you may very well have been asked this before - has he been tested (ideally multiple times) for nidovirus? This is also unfortunately one of the primary underlying causes seen in chronic RI cases with ball pythons, with similar symptoms - recurring respiratory distress despite treatment and without obvious triggers. My concern is that if it is indeed nidovirus rather than a fungal infection, that same virus could be transferred to any other snake you own or plan to own in the future, and if it is nidovirus, it is incurable and probably a safe and humane choice for him to euthanize in that case.

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Yes, he has been nido tested.

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Now, I’m not a vet, but this bit here seems…Odd based on the fact that this is a recurring problem with suspected fungal infection. Antibiotics/antimicrobials are going to do very little against anything fungal. I’m also kind confused, despite knowing he had long-term mold exposure, has he never been tested or treated for fungus? Obviously I don’t know his entire medical history, but if he’s only now being tested for a fungal respiratory infection, I’d be questioning the quality of previous care.

There’s also the fact that F10, while used for nebulization, is not FDA approved and is technically just a disinfectant that contains ingredients known to cause respiratory irritation/pulmonary toxicity (Benzalkonium chloride). Here are some threads discussing its use:

That said, checking the Merck Veterinary Manual:
“Suggested treatments for deep fungal respiratory infections include amphotericin B, itraconazole, fluconazole, and voriconazole.” I’d say that’d probably be the direction your current vet will go in depending on results.

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Wow I am truly sorry for the misery this poor little guy has suffered through for so many years! Tbh I don’t understand or am familiar with the technical terms and verbiage in your post because it is over my head but I do know that you and Jose are fighting a clearly uphill battle so I am sending you all the love :heart: and hugs :people_hugging: you can possibly imagine as well as all my best Auriea…….

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Wow i appreciate you looking into the antifungal meds out there! Any you are not wrong. The treatment he received has been off. With this vet especially.

This ties back into the issues I have experienced with the rescue that boarded my animals for a month who almost lost their vet privileges by claiming José was their snake.

José is being seen at that vet under my name now.
The event that led to the owner being caught for a false claim of ownership was me calling them after receiving his initial exam invoice to question the plethora of issues with his medical history, treatment, and physical assessment. (As i was not made aware of him beginning to wheeze and generally worsen while he was in her care.)

When he was initially taken in by the rescue owner, the severity of his illness was downplayed.
The test was offered right off, but she declined to do it without consulting me because, i can only assume, it was expensive. Due to those circumstances, the vet could only treat it like an average R.I.
I predicted right off that the shots weren’t going to work and i was right.
I had hope for the f-10 because they described it as being anti-fungal. As far as that goes, they do prescribe the Nebulization. With prediluted f-10 in a med bottle and everything. I know it is an out of pocket treatment, but i hear good and bad about it’s efficacy that has been very confusing. I had no idea it had chemicals that can CAUSE respiratory irritation/pulmonary toxicity. That’s very concerning to hear now that he’s already been treated with it.
It could explain then why he only seemed to be getting worse since treating him.

I’m now hopeful to see something change with Azithromyacin in place of the F-10SC. I have never heard of Azithromyacin being used in Nebulization, but I’m not a vet, this stuff goes wayy over my head, and that’s a big part of the difficulty with managing his treatment and determining who’s competent vs incompetent. I wish i could just take it on their authority without having to worry about how much of what they are saying is semi-educated spitballing vs actual tested medical knowledge.

I imagine that after this test comes back we will get to pinpoint one of those meds to actually treat him with. At this time, i don’t think either of the meds he’s on are intended to do much more than fend off the infection while we find the right med to treat the cause.

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This is a very frustrating issue when trying to seek vet care, especially for exotics. I recently had a bad experience while trying to seek treatment for a relatively minor issue with my chinchilla. This vet came highly recommended as the best in the area for small mammals, but I knew I made a big mistake going to her when she started berating me for not feeding my chin fresh fruits and veggies (which chins do not process well and can cause them all kinds of health problems). :roll_eyes: But when you start dealing with more medically complex issues involving pathogens and tests and drugs and dosages, it’s often really difficult for pet owners with no formal medical background to know if their vet is doing right by their animal.

I’m so sorry to hear that Jose isn’t doing well. I hope this current vet does know what they’re talking about, and that you’re able to figure out what’s going on and treat him effectively. It does sound like you might be on the right track. :crossed_fingers:

And thanks for sharing this. I think it’s really helpful and important to share stories like Jose’s, both for those who may be facing similar issues with their animals, as well as just general education for the community. You’re an incredible snake mamma. :heart:

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I’m really sorry that this is continuing and continuing and continuing. I got that you get good answers from the final tests. Fungus is so potentially horrible, potentially so terribly difficult to treat in animals and in humans. People just don’t realize.

I couldn’t say it better.

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I am so sorry you and José have gone through all of this, I’m glad you’ve been able to take back control over his care. It’s great that you’re sharing his story so that it might be able to help others. Hopefully testing will reveal a solid course to follow, treatment wise.

While he may not have had the best or most accurate care up until this point, it seems like the vet is doing their best to look into a deeper fungal infection now. It’s incredibly hard knowing what treatments to approve or not, especially with as little is known about reptiles in a veterinary setting and the lack of information available to us as owners. Sometimes you’ve just got to put your faith in someone and with skill and some luck, hopefully a more successful course of treatment will be found and he’ll get some long term relief. You’re doing the absolute best for him, and I’ll be wishing you both brighter days ahead. :people_hugging: :blue_heart:

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Thank you so much for posting this. I feel entirely defeated because I have been treating my ball python Archie since October of 2025 to present for and RI that’s just never left. Three exotic vets, 5 rounds of ceftazidime of 10 shots each (every 3 days), 3 shots of doxycycline every 7 days (at the same time as ceft), two weeks of once daily f10sc nebulization, and literally nothing has changed. He’s had a whistle and a small mucus bubble show when he yawns. His frequency of yawning is more than it should be. His X-rays showed that he was not super progressed back in January. His bloodwork however had a white blood cell count that was 35k so we sent it out for pathology thinking it might be cancer but it turned out not to be so that’s ruled out. He has stopped eating as of 3/22/26 which was the last time he ate. He has lost almost 30+ grams in weight weighing a measly 623 grams now at 2 years old. I’m so afraid he is going to die on me. None of these vets told me to do testing other than blood or xray. I’m going to try a 4th exotic vet and request immediate testing in hopes it’s not too late for him. I’ve been googling my ass off in hopes of finding someone else who has been in my shoes. I have redone and reworked his husbandry a million times to ensure it’s correct. I desperately want to know if your boy Jose was cured and if so what finally worked. I pray he was cured! Please if you could post a follow up for me as I’m losing all my hair dealing with this and my hearts breaking for him. I just want my boy better.

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@auriea I hope you see my reply to Jose’s story. I am desperately seeking an answer 🫶🏻

Firstly, i just want to say I’m so sorry you are going through this with little Archie. It’s really freaking tough and you obviously care really deeply. I don’t know how much of Josés story directly translates, but I’ll help however i can, even if that’s just someone to talk to who’s been there.

José is still alive. He just celebrated his 11th birthday a couple of weeks ago.

After the last post on this, a lot of stuff happened. We went to a different boarder, he went through another full set of meds, full quarentine. And then we moved. And then moved again. And once again for good measure.
There’s been a lot of transition.

I can’t say that we found the cure. Or even pinpointed the cause outside of just pre-existing tracheal scarring and stress. The fungal test ultimately came back negative. Viral tests are negative. He’s a medical mystery to this day. His health didn’t start turning around until I finally got him back home with me for the first time since the incident that had us searching for boarders. I couldn’t tell you why. I wish I could be more definitive.

Honestly, at best he has achieved remission. Yet, the cumulative stressors of all of his medical struggles and the moves and the incidents eith the different folks have pretty significantly impacted him mentally. He hasn’t been the same since and that’s honestly been really hard to cope with. I was just talking with my coworker about it yesterday.

He has behavioral issues now where he will randomly stress and refuse to settle to the point of self-mutilation. He’s scarred up his face pretty good from trying to escape his enclosure. It’s usually when he poops or pees. He does not tolerate being enclosed with his waste for an hour. Which gets difficult considering that I am at work for 8 to 12 hours a day and in college on the weekends.

I have one or two more tricks up my sleeve for him. I want to try full-bio with the best lighting and heating and control that money can buy. I believe in the immune boosting effects of full-spectrum lighting, and i believe that the fresh-petrichor scent of a healthy bio mught soothe his lungs. But it is a bit change with a ton of expense and I’m still working on affording all of it.

I’ve also looked into scheduling Lori Torrini via her website for snake-based behavioral therapy of sorts. I’m just hoping to make enough progress on the bio front that i can at least say i have the ability to immediately move forward with improvements when I talk to her. I’m really hoping that she will allow me some insight that will help me make his life more worth living.

But if for one reason or another, all that doesn’t work, or I cannot get progress on it in what i condiser to be a reasonable amount of time for his needs and my financial limitations, I can at least say I have truly given it my best shot. And then he will be humanely euthanized.

In any case, I can say that he would have never made it to 11 in any other home he could have ended up in, if not mine, given where he came from. That means something no matter what happens. But I do so very dearly miss the boy I had before the relapse. I miss being able to hold him and take him outside and hang out with him like I used to. I miss him being a goof. Now he’s either sleeping or stressing or I can’t touch him because he seems fine and I can’t get myself to disturb him for fear of breaking the moment like a spell.

I really wish I could give you more. For me, it’s not as urgent as it was once before, but ultimately, it is a question of quality of life. Unfortunately, we have to make that decision for them. And there is no right choice in that situation.

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:pleading_face::pleading_face::pleading_face: ugh my heart breaks for you too. I was really hoping you had gotten it all sorted and he was fully recovered. Don’t give up hope yet. I am glad to hear he is still alive though and even happier to hear of the sort of remission you mentioned. I’m baffled that no cause was found and I’m praying to the universe that this won’t be Archie’s story. I am going to go through the testing (that no vet mentioned to me prior) in hopes that sheds some light. The ceft and nebulization just isn’t working. I’ve seen no improvement. I will say that thinking back, the 3 shots of doxy I think did cause whatever he’s got going on to improve a bit. After those is when the vet cleared him and said he was all better (but he still had a whistle so I was weary and I was right). The testing is super expensive here by me in NY. $700+ just for the pcr test. That’s not counting any other test nor the lung flush/swabbing cost. I’m gonna do it anyway but I hope I get something back so we can do right by him.

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I am really sorry to hear about José. It is really frustrating to have visited so many vets and still not have clear answers, we have such a long way to go in reptile medicine. I am from Australia and have a children’s python and have a similar story. My Nilsson has had chronic RIs for the past 12+ months.

The first vet I took him to treated with ceftazidime without doing any swabs or cultures, which improved his symptoms at first but then about 4 months after finishing the course he went back to open mouth breathing, gaping and wheezing. So she restarted the course and we did another 7 cefta shots over several weeks, every 3 days. He seemed to improve a bit, but then symptoms returned after a few weeks. Extended the cefta shots again. At this point we got a full viral panel done and everything was negative, and I really should have insisted to try a different antibiotic but I was trusting the vets judgement.

After yet another course of cefta (4 courses total now) and an even shorter relapse after a brief recovery, I took him to a different vet. They prescribed TMS instead which he took for a week, while we waited for bacterial swab culture and sensitivity results. The results were a bit inconclusive because the species they detected could just be normal microflora, but the new vet suggested it could be an opportunistic pathogen (Enterococcus and Klebsiella). So they started him on weekly doxycycline injections for four weeks.

He made huge improvements a few weeks after his last doxycycline shot, although the injection sites went a bit necrotic on the surface which the vet reassured can happen and eventually went away after he shed (he has scars now though). He has been better for about two months, back to long tongue flicks, no gaping, eating fine, active, etc.

But just over the past week he has started having symptoms again, short tongue flicks, gaping, red and swollen around the mouth. I am heartbroken, I honestly thought he was truly on the mend after the doxy treatment. I’m honestly running out of ideas guys, I have changed every husbandry parameter I can and am pretty pedantic about maintaining the right temperatures and humidity, keeping clean water, etc.

I love my little Nilsson, he is so sweet and he is my first snake. I don’t know what could have caused this except for him being in a bioactive enclosure previously. He is a colour morph which my vet suggested might mean he is less hardy/robust than the natural variations. He is still eating fine and is quite active, he doesn’t have any saliva around his mouth so I would say his quality of life isn’t bad. But I know that this won’t be sustainable for me or for him forever if he continues falling sick all the time, emotionally, for his health and for my limited financial capacity. I have had to mentally prepare for the possibility of euthanasia which breaks my heart, how do you know when it’s time? As I said earlier, his quality of life is actually okay at the moment, but what am I meant to do if I can’t keep affording treatment?

I’m a recent uni graduate and haven’t yet started my new grad role and I am running out of money to treat him (I’ve spent most of my savings on him). I start my first graduate role in just under two months but I’ve got to keep him afloat with the minimum income I currently recieve. What is the right thing to do here? Just continue antibiotic injections and hope for the best? The costlier options of doing scans at a private specialist such as SASH in Sydney can cost several thousand $ and I simply can’t afford that. What do you do at that point when you can’t afford that type of treatment? Any advice or shared experiences would be appreciated. I feel super lost.

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So just to update, we did the pcr and culture sensitivity tests and it came back that his RI is being caused by a bacteria called Pseudomonas. We are going to begin treatments using and injectable piperacillin-tazobactam antibiotic which I think is also called zosyn. Fingers crossed that this will be the answer for him. 🫶🏻

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